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Effects of the

Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 4,   Pages 314-320 doi: 10.15302/J-FASE-2014038

Abstract: This study was conducted to systematically assess the reproductive performance of transgenic ewes.In the transgenic founders (F ) and their positive offspring (F ), hematological and reproductive parametersand biochemical parameters determined from the blood samples did not differ significantly between the transgenicMoreover, the transgenic ewes showed reproductive traits similar to the wild-type ewes.Additionally, no significant differences were found between transgenic and wild-type ewes in the DNA

Keywords： TLR4 transgenic ewe     safety assessment     reproductive trait     oocyte     DNA methylation    

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acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like receptor 4

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 292-301 doi: 10.1007/s11684-020-0806-5

Abstract: B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65, IKKα/β,that the B-HA attenuated the LPS-stimulated inflammatory response by inhibiting the activation of the TLR4

Keywords： bioactive hyaluronan     lipopolysaccharide     inflammatory cytokines     TLR4     human macrophages    

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regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions in both transgeniccells and transgenic mice

Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 87-96 doi: 10.15302/J-FASE-2016087

Abstract: that the pMAR-CAG-FST-IRES-AcGFP1-polyA-MAR (pMAR-FST) vector had higher capacity to form monoclonal transgenicRemarkably, protein expression in transgenic cells with the pMAR-FST vector was significantly higherExogenous was expressed in all of the pMAR-FST transgenic mice at F , F and F .mice was significantly greater than in wild-type mice, with larger muscles in fore and hind limbs of transgenicmice. pMAR-FST transgenic mice were also found with more evenly distributed muscle bundles and thinner

Keywords： safety of transgenic     bicistron gene transfer body     transgenic mice     muscle development    

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Advances of Transgenic Breeding on Rapeseed (Brassica napus)

Guan Chunyun

Strategic Study of CAE 2002, Volume 4, Issue 8,   Pages 34-39

Abstract: It described advances of transgenic breeding of rapeseed (Brassica napus) in Oil Crops Institute, HunanThe. paper dealt with Bt-transgenic insect-resistant rapeseed line, transgenic sterile line, restorerline and their hybrid, transgenic high oleic acid content rapeseed line and transgenic high oil content

Keywords： rapeseed     transgenic     breeding    

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Enlighenments for China from the Industrialization of the Transgenic Atlantic Salmon in the US

Hu Wei and Zhu Zuoyan

Strategic Study of CAE 2016, Volume 18, Issue 3,   Pages 105-109 doi: 10.15302/J-SSCAE-2016.03.018

Abstract: the US Food and Drug Administration (FDA) approved the "all fish" growth hormone (gh) transgenicgenetically engineered livestock approved for human consumption and is considered as breakthrough of transgenicThe US FDA made this landmark decision after 20 years rigorous bio-safety assessment of the transgenicBoth the scientific research behind the creation of this transgenic product and the active participation

Keywords： transgenic     Atlantic salmon     industrialization     enlightenments    

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Construction of multiple shRNA vectors targeting PEDV and TGEV and production of transgenic SCNT porcine

Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 66-72 doi: 10.15302/J-FASE-2018229

Abstract: transfected into porcine fetal fibroblasts, G418 resistant transfectants were confirmed by PCR and transgenicThese results have paved the way for future production of marker-free transgenic resistant to PEDV and

Keywords： piglet diarrhea     RNAi     PEDV     TGEV     transgenic resistance breeding    

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Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 3,   Pages 179-184 doi: 10.15302/J-FASE-2014020

Abstract: One potential method is to produce transgenic livestock that make modified milk containing high concentrationSubsequently, we injected the BAC construct into pronuclei of mouse fertilized embryos and generated transgenicanalysis showed that recombinant hBCHE (rhBCHE) was expressed efficiently in the mammary gland of the transgenicOur results pave the way for making transgenic livestock to produce large quantities of rhBCHE.

Keywords： recombinant human butyrylcholinesterase (rhBCHE)     human lactoferrin bacterial artificial chromosome (hLF BAC)     transgenic    

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conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain transgenic

Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO

Frontiers of Agricultural Science and Engineering 2014, Volume 1, Issue 2,   Pages 158-173 doi: 10.15302/J-FASE-2014015

Abstract: Bovine IgM was highly expressed in selected transgenic lines, and it largely inhibited rearrangementsAlthough the serum concentrations of endogenous IgM and IgG in the transgenic mice were significantlyThese transgenic mice also exhibited a lower frequency of unique complementarity determining region 3Compared to the WT mice, the transgenic mice had a significantly higher percentage of mouse IgM-expressingFinally, we showed that the transgenic mice were deficient in a specific antibody response to antigen

Keywords： bovine Ig μ heavy-chain     transgenic mice     B cell development     allelic exclusion     immune response     Ig repertoire    

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Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 288-303 doi: 10.1007/s11684-015-0412-0

Abstract: Accumulating evidence suggests that TLR signaling is involved in normal hematopoiesis and specific hematologicSterile activation of TLR signaling is required to generate early embryonic hematopoietic progenitorIn adult animals, TLR signaling directly or indirectly promotes differentiation of myeloid cells at theActivating mutations of the MyD88 gene, which codes for a key adaptor involved in TLRDysregulated TLR signaling contributes to the pathogenesis of many hematopoietic disorders, including

Keywords： TLR     MyD88     hematopoiesis     bone marrow failure     leukemia     myelodysplastic syndrome    

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ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 11,   Pages 1728-1740 doi: 10.1007/s11705-023-2322-z

Abstract: A novel Z-scheme ZnFe2O4/BiVO4 heterojunction photocatalyst was successfullyCompared with the single-phase counterparts, ZnFe2O4/BiVO4 demonstratedConsequently, the 30% ZnFe2O4/BiVO4 catalyst afforded a degradationorganic carbon removal rate of 50%, which is an excellent activity compared with ever reported BiVO42O4/BiVO4 heterojunctions were quite

Keywords： ZnFe2O4/BiVO4     Z-scheme heterojunction     photocatalytic degradation    

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Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

Frontiers in Energy 2017, Volume 11, Issue 3,   Pages 374-382 doi: 10.1007/s11708-017-0494-2

Abstract: The preparation of Li SiO -coated LiNi Mn O materials by sintering the SiO -coated nickel-manganese oxides with lithium salts using abundant and low-cost sodium silicate as the silicon source was reported. The samples were characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. It was found that a uniform and complete SiO coating layer could be obtained at a suitable pH value of 10, which transformed to a good Li SiO coating layer afterwards. When used as the cathode materials for lithium-ion batteries, the Li SiO -coated LiNi Mn O samples deliver a better electrochemical performance in terms of the discharge capacity, rate capability, and cycling stability than that of the pristine material. It can still deliver 111.1 mAh/g at 20 C after 300 cycles, with a retention ratio of 93.1% of the stable capacity, which is far beyond that of the pristine material (101.3 mAh/g, 85.6%).

Keywords： lithium-ion batteries     cathode material     LiNi0.5Mn1.5O4     lithium-ion conductor    

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Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 3, doi: 10.1007/s11783-020-1224-2

Abstract: zero-valent zinc coupled with ascorbic acid (ZVZ/AA) was developed and applied to debrominate the 2,2′,4,4ZVZ particles and 3 mmol/L AA at original solution pH= 4.00 using the solvent of methanol/H2O (v:v= 4:

Keywords： 2     2′     4     4′-tetrabromodiphenyl ether (BDE-47)     Ascorbic acid     Reductive debromination     Zero-valent zinc    

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Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 132-142 doi: 10.1007/s11684-022-0938-x

Abstract: In the present study, replication factor c subunit 4 (RFC4) is a key potential target involved in NPCFurthermore, the expression and mechanism of RFC4 in NPC were investigated in vitro and inOur results revealed that RFC4 was more elevated in NPC tumor tissues than in normal tissues.RFC4 knockdown induced G2/M cell cycle arrest and inhibited NPC cell proliferation in vitro andInterestingly, HOXA10 was confirmed as a downstream target of RFC4, and the overexpression of HOXA10

Keywords： nasopharyngeal carcinoma     WGCNA     RFC4     proliferation    

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Laws of 4D Printing Article

Farhang Momeni, Jun Ni

Engineering 2020, Volume 6, Issue 9,   Pages 1035-1055 doi: 10.1016/j.eng.2020.01.015

Abstract: Accordingly, four-dimensional (4D) printing is a manufacturing process that involves multiple researchfields. 4D printing conserves the general attributes of 3D printing (such as material waste reductionThe main difference between 3D- and 4D-printed structures is the presence of one additional dimensionshow that two types of time constants are needed to capture the correct time-dependent behavior of 4Dintroduce the concept of mismatch-driven stress at the interface of active and passive materials in 4D

Keywords： Manufacturing     Stimuli-responsive materials     Mechanics of materials     Time constant     4D printing    

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Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 7,   Pages 1090-1100 doi: 10.1007/s11705-021-2091-5

Abstract: Twenty six novel pyrimidin-4-amine derivatives containing the 1,2,4-oxadiazole motif were synthesized

Keywords： synthesis     pyrimidin-4-amine derivatives     1     2     4-oxadiazole     insecticidal activity     structure-activity    

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Title Author Date Type Operation

Effects of the

Yi FANG,Xiangwei FU,Junjie LI,Ming DU,Baoyu JIA,Jinlong ZHANG,Xiaosheng ZHANG,Shien ZHU

Journal Article

acid fragments inhibit lipopolysaccharide-induced inflammatory responses via the Toll-like receptor 4

Na You, Sasa Chu, Binggang Cai, Youfang Gao, Mizhou Hui, Jin Zhu, Maorong Wang

Journal Article

regions included in a bicistronic vector enhances and stabilizes follistatin gene expressions in both transgeniccells and transgenic mice

Xiaoming HU,Jing GUO,Chunling BAI,Zhuying WEI,Li GAO,Tingmao HU,Shorgan BOU,Guangpeng LI

Journal Article

Advances of Transgenic Breeding on Rapeseed (Brassica napus)

Guan Chunyun

Journal Article

Enlighenments for China from the Industrialization of the Transgenic Atlantic Salmon in the US

Hu Wei and Zhu Zuoyan

Journal Article

Construction of multiple shRNA vectors targeting PEDV and TGEV and production of transgenic SCNT porcine

Jianwen CHEN, Kaiyuan PAN, Zhen CHEN, Biao DING, Dandan SONG, Wenbin BAO, Yunhai ZHANG

Journal Article

Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice

Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI

Journal Article

conventional mature B cells and compromised specific antibody response in bovine immunoglobulin μ heavy-chain transgenic

Min ZHANG,Xueqian CHENG,Dan CHU,Jingwen LIANG,Yi SUN,Li MA,Beilei XU,Min ZHENG,Meili WANG,Liming REN,Xiaoxiang HU,Qingyong MENG,Ran ZHANG,Ying GUO,Yunping DAI,Robert AITKEN,Ning LI,Yaofeng ZHAO

Journal Article

Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases

Joseph Cannova,Peter Breslin S.J.,Jiwang Zhang

Journal Article

ZnFe2O4/BiVO4 Z-scheme heterojunction for efficient visible-light photocatalytic

Journal Article

Li4SiO4-coated LiNi0.5Mn1.5O4 as the high performance

Shifeng YANG, Wenfeng REN, Jian CHEN

Journal Article

Enhanced debromination of 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) by zero-valent zinc with ascorbic

Chaojin Jiang, Xiaoqian Jiang, Lixun Zhang, Yuntao Guan

Journal Article

Knockdown of RFC4 inhibits the cell proliferation of nasopharyngeal carcinoma and

Journal Article

Laws of 4D Printing

Farhang Momeni, Jun Ni

Journal Article

Synthesis, insecticidal activities and DFT study of pyrimidin-4-amine derivatives containing the 1,2,4

Journal Article